Hmm, just tried this. I tried opening the chest a number of times and the skeletons e.t.c always seemed to spawn in the same place, a set of groups outside each entrance to the small inner room, but back a little from the entrance. I'm not sure if it is fixed, or if it's set when you enter the dungeon but it's certainly not random when you open the box. They're far enough away from the door so if you open the chest at max range (you will be fairly close to a door), you can turn around, look at the skeletons, then come out of turnbased mode and run past them. You'll get hit a few times as you pass, but if you survive that you can run like a bunny for one of the corner passages and then start patiently sniping the skels 
Note that this only works if you enter turn-based mode before you open the chest. If you do it after you close the chest, even if you do it immediately all the skels get one turn of movement, which is likely to put skeletons right in the doorways where you can't get past them...
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