I don't have any examples from MM7, but in MM6 I routinely get the relic chain mail Apollo for one of my characters. It adds 20 to all Resistances and to Luck, and its ability to lower Endurance by 30 usually costs the character wearing it about 3 hit points - which is neither here nor there. I would look a lot harder at those relics. They may be more useful than you think. I wouldn't take on anything that lowers all Resistances without a very good reason, and I would think hard about something that lowered Speed or a character's primary stat too far, but I would be quite relaxed about some of the other stats.
