(1) The chests in the Castle *are* safe. They will never reset, not even when the Castle upgrades. Also, they are the only chests, which are safe during the whole game.
As far as other chests are concerned, you must know when the area resets: the chests are safe until reset, then all chests in the area are emptied, reloaded with random itmem like at the beginning of the game, and locked.- Walls of Mists and Breeding Zone reset every time you enter them - storing items there is unpossible.
- Barrow Downs, Evermorn Island, and Lands of Giants reset every 6 months.
- All other areas, including all interiors (dungeons) reset every 2 years. This is also true for all interiors in areas, which reset every 6 months. For example, Stone City and dungeons at Barrow Downs reset every 2 years.
- The chests in the Castle never reset even if the Castle is upgraded twice.
The "resetting period" begins when the area is "ready to reset" and you enter it. This is exactly the moment when the chests reset. When you start the game, all areas are "ready to reset".
Thus, the resetting periods will start differently - as you have entered the areas, and also elapse in different moments.
(2) MM8: *No* chest in MM8 is safe! Even the chests in the tradehouse reset!