It ran well. No problems setting up a party and doing a first run through temple on Emerald Island. When I reloaded, the music wouldn't play, although it had been playing. The configuration tool wouldn't load, and then the game became very trippy, running in boxed windows, etc. I set it to run maximized and checked compatibility, etc, but that made things worse.
So, I uninstalled, then reinstalled, and now I get an error which reads "The procedure entry point_AIL_lock_mutex@0 could not be located in the dynamic link library mss32.dll. That will pop up twice, but I can get into the configuration tool, however I cannot launch the game.